Big Submarine launched (Belgorod project)
April 28, 2019
Big Eagles on moving
April 28, 2019
Synthetic Cartilage
April 28, 2019
Biomacromolecules. 2019 Apr 22.
doi: 10.1021/acs.biomac.9b00237. [Epub ahead of print]
Double Network Hydrogels that Mimic the Modulus, Strength and Lubricity of Cartilage.
Means AK, Shrode CS, Whitney LV, Ehrhardt DA, Grunlan MA.
Abstract
The development of a hydrogel-based synthetic cartilage has the potential to overcome many limitations of current chondral defect treatments. Many efforts have attempted to replicate the unique characteristics of cartilage in hydrogels, but none simultaneously achieved high modulus, strength and toughness while maintaining the necessary hydration required for lubricity. Herein, double network (DN) hydrogels, composed of a poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) 1st network and a poly(N-isopropyl-acrylamide-co-acrylamide) [P(NIPAAm-co-AAm)] 2nd network, are evaluated as a potential off-the-shelf material for cartilage replacement. While predominantly used for its thermosensitivity, PNIPAAm is employed to achieve superior mechanical properties and its thermal transition temperature tuned above the physiological range. These PNIPAAm-based DNs demonstrate a 50-fold increase in compressive strength (~25 MPa, similar to cartilage) compared to traditional single network hydrogels while also achieving a cartilage-like modulus (~1 MPa) and hydration (~80%). By directly comparing to healthy cartilage (porcine), these hydrogels are confirmed not only to parallel the strength, modulus and hydration of native articular cartilage but also exhibit a 50% lower coefficient of friction (COF). The exceptional cartilage-like properties of the PAMPS/P(NIPAAm-co-AAm) DN hydrogels makes them candidates for synthetic cartilage grafts for chondral defect repair, even in load-bearing regions of the body.
PMID:
31009565
DOI:
10.1021/acs.biomac.9b00237
Cyrus Cylinder and Cuneiform Writing
April 26, 2019
They were very religious – believing to Strong Gods and Divine powers and they were great warriors. Their Viking King Harald learned that Jesus Christ was the Son of God , the Real Living God, and took the baptims in his Name 826 A.D. and made all his people Christians by the same. That time they used Futhark alphabet and some written stones describe the beginning of Christianity in Denmark. Also the letters of Latin was taken to usage because they were more easy and the communication become much easier when the Christianity became religion in the country..
These pictuers are from Jelling City, These are handicrafts.copies, showing to school children the text and pictures from the original stones, which are very carefully guarded because they are UNESCO Wolrd Heritage.
http://www.copenhagenet.dk/CPH-Map/DK-Denmark-Jelling.asp
Iran Floodings Aftermath
April 24, 2019
Uppdatera 19 Apr. 2019 Relief Web
Over 1,000 health facilities destroyed or damaged: UNICEF vaccines cold chain equipment arrives in country
Multimedia available here
TEHRAN, 19 April 2019 – Devastating flooding in three quarters of Iran’s provinces has affected 10 million people, of whom 2 million are severely impacted and 500,000 displaced – half of them are children. Over 1,000 health facilities and 1,000 schools have been destroyed or severely damaged forcing 100,000 children out of school and depriving thousands of essential healthcare.
UNICEF’s vaccine cold chain equipment, including 200 vaccine carriers and 100 cold boxes, arrived in-country last night. The equipment will help restore essential immunization services for children in affected provinces and prevent the spread of diseases. Eighty vaccine refrigerators have also been dispatched.
The needs of flood-affected children in Iran are getting more acute by the day and more supplies are urgently needed.
Russia: Easter celebration disturbed in Moscow Synagogue
April 19, 2019
Hindgavl Castle 2019,Denmark
April 19, 2019
Wonderful Park round the castle ( a conference hotel).
http://www.danskeherregaarde.dk/nutid/hindsgavl
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