Big Eagles on moving

April 28, 2019

Synthetic Cartilage

April 28, 2019

Biomacromolecules. 2019 Apr 22.

doi: 10.1021/acs.biomac.9b00237. [Epub ahead of print]
Double Network Hydrogels that Mimic the Modulus, Strength and Lubricity of Cartilage.
Means AK, Shrode CS, Whitney LV, Ehrhardt DA, Grunlan MA.

The development of a hydrogel-based synthetic cartilage has the potential to overcome many limitations of current chondral defect treatments. Many efforts have attempted to replicate the unique characteristics of cartilage in hydrogels, but none simultaneously achieved high modulus, strength and toughness while maintaining the necessary hydration required for lubricity. Herein, double network (DN) hydrogels, composed of a poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) 1st network and a poly(N-isopropyl-acrylamide-co-acrylamide) [P(NIPAAm-co-AAm)] 2nd network, are evaluated as a potential off-the-shelf material for cartilage replacement. While predominantly used for its thermosensitivity, PNIPAAm is employed to achieve superior mechanical properties and its thermal transition temperature tuned above the physiological range. These PNIPAAm-based DNs demonstrate a 50-fold increase in compressive strength (~25 MPa, similar to cartilage) compared to traditional single network hydrogels while also achieving a cartilage-like modulus (~1 MPa) and hydration (~80%). By directly comparing to healthy cartilage (porcine), these hydrogels are confirmed not only to parallel the strength, modulus and hydration of native articular cartilage but also exhibit a 50% lower coefficient of friction (COF). The exceptional cartilage-like properties of the PAMPS/P(NIPAAm-co-AAm) DN hydrogels makes them candidates for synthetic cartilage grafts for chondral defect repair, even in load-bearing regions of the body.


Dr. Irvin Finkel teaching Cuneiform

The Cyris Cylinder:

They were very religious – believing to Strong Gods and Divine powers and they were great warriors. Their Viking King Harald learned that Jesus Christ was the Son of God , the Real Living God, and took the baptims in his Name 826 A.D. and made all his people Christians by the same. That time they used Futhark alphabet and some written stones describe the beginning of Christianity in Denmark. Also the letters of Latin was taken to usage because they were more easy and the communication become much easier when the Christianity became religion in the country..These pictuers  are from Jelling City, These are  handicrafts.copies,   showing to school children the text and pictures   from the original stones, which  are  very carefully  guarded  because they are UNESCO Wolrd Heritage.


Iran Floodings Aftermath

April 24, 2019

Uppdatera 19 Apr. 2019  Relief Web

Over 1,000 health facilities destroyed or damaged: UNICEF vaccines cold chain equipment arrives in country

Multimedia available here

TEHRAN, 19 April 2019 – Devastating flooding in three quarters of Iran’s provinces has affected 10 million people, of whom 2 million are severely impacted and 500,000 displaced – half of them are children. Over 1,000 health facilities and 1,000 schools have been destroyed or severely damaged forcing 100,000 children out of school and depriving thousands of essential healthcare.

UNICEF’s vaccine cold chain equipment, including 200 vaccine carriers and 100 cold boxes, arrived in-country last night. The equipment will help restore essential immunization services for children in affected provinces and prevent the spread of diseases. Eighty vaccine refrigerators have also been dispatched.

The needs of flood-affected children in Iran are getting more acute by the day and more supplies are urgently needed.

Wonderful Park round the castle ( a conference hotel).

Iran, Karkeh Dam

April 9, 2019

Leabright's Blog

Just another weblog is the best place for your personal blog or business site.