DOI: 10.1126/science.abb9983


Review Oxygen and viruses: a breathing storyFre ́de ́ric Morinet,1Mathilde Parent,2Corinne Bergeron,3Sylvie Pillet4andClaude Capron

Article Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients, Graphical Abstract
*Viral-Track: a computational framework to analyze host-viral infection maps
*Viral-Track sorts infected from bystander cells and reveals virus-induced expression
*SARS-CoV-2 infects epithelial cells and alters immune landscape in severe patients
* Co-infection of SARS-Cov-2 and hMPV affects monocytes and dampens interferon response
Authors Pierre Bost, Amir Giladi, Yang Liu, …,Benno Schwikowski, Zheng Zhang, Ido Amit Correspondence (B.S.), (I.A.), (Z.Z.)In Brief A computational framework that allows for the identification and characterization of virus-infected cells as well as bystander cell responses reveals how SARS-CoV-2 alters the immuneresponses of patients. Bost et al., 2020, Cell181, 1–14June 25, 2020ª2020 Elsevier Inc.

Conclusions: Remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; ACCT-1 number, NCT04280705.).

Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex

Hazel M. Girvan†, Justin M. Bradley‡, Myles R. Cheesman‡, James R. Kincaid§, Yilin Liu§, Kazimierz Czarnecki§, Karl Fisher†, David Leys†, Stephen E. J. Rigby†, and Andrew W. Munro*†

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Cite this: Biochemistry 2016, 55, 36, 5073–5083
Publication Date:August 20, 2016

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