Citate.” It is now well established that cGAS is a major sensor of microbial pathogens that contain DNA or generate DNA in their life cycles. New studies have illuminated an equally critical role of cGAS in the surveillance of self-DNA that mislocalizes to the cytoplasm under pathological conditions. Although decades of research have led to a good understanding of how genotoxic stress and genomic instability regulate DNA damage repair, cell cycle checkpoints, and programmed cell death, the mechanism by which DNA damage leads to inflammation and autoimmunity was not well understood until recently. In retrospect, it is logical that cGAS is well positioned to connect nuclear DNA damage to immune responses because cGAS can be activated by any dsDNA that enters the cytoplasm. It is interesting to note that in addition to chemical and radiation damage to DNA, many other biological processes such as oncogene activation, telomere shortening, and cell division errors all impinge on DNA. Although NF-κB is well known to play an important role in mediating inflammatory responses to DNA damage (Janssens and Tschopp, 2006), the link between DNA and NF-κB was not clear. Now cGAS has emerged as an important link between DNA damage and activation of NF-κB, IRF3, and likely other transcription factors.”

Mini review

Stimulator of interferon genes (STING): A “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity


February 23, 2019

23.2. 2019
Belarus: Mass grave uncovered at site of former ghetto

Construction suspended after hundreds of bodies found at former Jewish ghetto of Brest, Belarus.

The Lunar  module is  travelling  circuitous route ,  increasing  orbit diameter ,  first    round the Earth  some times  and then departing  from the gravity forces of  the Earth  towards  the Moon and its gravity sphere,    orbiting  the Moon  and then  descending at last  to  the Lunar surface .  It gives  geomagnetic  data from  the Moon.

Primary Language:  Pemon

Bible Translation Status  (Years)
Bible-Portions Yes  (1990)
Bible-New Testament No
Bible-Complete No

Thousands riot along Gaza border fence

The IDF said that around 8,000 Palestinian Arabs demonstrated at various points along the Gaza border on Friday.

The protesters set tires ablaze and threw grenades, incendiary devices and rocks towards the soldiers, an IDF spokesperson told AFP.

Israeli forces “responded with anti-riot means and shot according to the operational procedures,” said the spokesperson.

(Arutz Sheva’s North American desk is keeping you updated until the start of Shabbat in New York. The time posted automatically on all Arutz Sheva articles, however, is Israeli time.)
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Naharaim, The Twinriver

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Jordan River basin

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