July 3, 2020


(The Article In Swedish): Svensson AM, Hansen T et al.  Radiologisk och histologisk bild för en ökad förståelse vid covid-19

Läkartidningen. 2020;117:20086
Läkartidningen 25-27/2020




2020 Apr 27;142:109783. doi: 10.1016/j.mehy.2020.109783. [Epub ahead of print]

Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection.






Teams are pursuing a dizzying array of therapeutic strategies to stymie COVID-19. It’s not yet clear which approach, or combination of approaches, will work best.

In late February, when reports of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in California started to emerge, Nevan Krogan’s molecular biology lab went into overdrive. Everyone in the lab switched to studying how viral proteins affect host cells. The group, at the University of California, San Francisco, came up with a schedule of lab shifts to work around the clock while maintaining at least six feet of space between colleagues. Although a mass spectrometer broke down and the group failed to synthesize three viral proteins, the last pieces of data—revealing which host proteins interacted with viral proteins—came in just as the lab shut down to comply with the state’s shelter-in-place orders.

Last month, the team published a preprint describing 69 potential drugs—24 of them already approved by the US Food and Drug Administration (FDA) for other diseases—that could help treat coronavirus disease 2019 (COVID-19) patients. The team identified the drugs by studying how 26 of the virus’s 29 proteins interact with host cells (1). In cell cultures, the researchers used synthetic versions of viral proteins to uncover the human proteins that bound to each viral molecule. Then they identified small molecules that bind to the host proteins or otherwise interact with them via cellular pathways.

The host–virus interactions that Krogan’s lab identified offer up clues as to why this new coronavirus causes symptoms that range from diarrhea and an inability to smell, to pneumonia and fatal multiorgan failure. “Other coronaviruses are similar but not as virulent,” Krogan says. “In terms of protein interactions, this virus seems to hijack and rewire so many different cellular pathways—it gets its fingers into all the key machinery of a cell.”



COVID-19 Outbreak: An Overview

Ciotti M.a · Angeletti S.b · Minieri M.c,d · Giovannetti M.e · Benvenuto D.f · Pascarella S.g · Sagnelli C.h · Bianchi M.g · Bernardini S.c,d · Ciccozzi M.f

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Research News

March 19, 2020



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