The Lancet: A cohort of 41 COVID-19 patients
February 27, 2020
To be healthy , to have a physiologically normally functioning Renin-angiotensin system
February 27, 2020
– then your renin- angiotensin system produces the dipeptide VY … a cleavage product size Ang-(3-4): The Researchers have found that this natural product of normal renin-angiotensin system can even exogenously be beneficial. When VY is functional, there must be an ideal homeostasis between the two main axis of Renin -angiotensin system and even KKK system ( kininogen-kallikrein system):
RAS 2 main axis:
ACE1-AngII-AT1R axis
ACE2-Ang-(1-9)- MasR axis.
Abstract
1. Intact absorption of the bioactive dipeptide Val-Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10-fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 +/- 145 vs 159 +/- 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t1/2) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 +/- 688 fmol small middle doth/mL plasma.
- PMID:
- 11906484
- DOI:
- 10.1046/j.1440-1681.2002.03628.x
- [Indexed for MEDLINE]
Renin-angiotensin system , many faces
February 27, 2020
https://benthamopen.com/FULLTEXT/TOOPHTJ-11-122
Youll find here a very good map of RAS and KKK system! https://openophthalmologyjournal.com/VOLUME/11/PAGE/122/
COVID-19. Deep-dive
February 26, 2020
ACE2-dimer research, ACE2 is a chaperone to intestinal cell neutral aminoacid transporter SLC6A19
February 25, 2020
https://www.biorxiv.org/content/10.1101/2020.02.17.951848v1.full#F4
ACE2 effective receptor to nCoV S protein
ACE and ACE2 enzymes
February 25, 2020
ACE and ACE2 in Inflammation: A Tale of Two Enzymes
Author(s): Ravinder Reddy Gaddam, Stephen Chambers, Madhav Bhatia.
Journal Name: Inflammation & Allergy – Drug Targets (Discontinued)
(Formerly Current Drug Targets – Inflammation & Allergy)
Volume 13 , Issue 4 , 2014
DOI : 10.2174/1871528113666140713164506
What we know and what we do not know anout the new SARS2 virus ?
February 23, 2020
Syrian Refugees and relentless situation
February 22, 2020
Detail information about current SARS CoV-2 and COVID-19
February 21, 2020
SARS-CoV-2 , COVID-19, and Europe
February 21, 2020
Click to access SARS-CoV-2-risk-assessment-14-february-2020.pdf.pdf
The virus: SARS-CoV-2
The disease, caused by SARS-CoV-2, is COVID-19.