The Lancet: A cohort of 41 COVID-19 patients

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

To be healthy , to have a physiologically normally functioning Renin-angiotensin system

– then your renin- angiotensin system produces the  dipeptide VY …  a cleavage product size Ang-(3-4): The Researchers have  found  that this natural product of  normal renin-angiotensin system  can even  exogenously  be beneficial. When VY is functional,  there   must be  an ideal homeostasis  between  the two main axis of Renin -angiotensin system and even KKK system ( kininogen-kallikrein system):

RAS 2 main axis:

ACE1-AngII-AT1R axis

ACE2-Ang-(1-9)- MasR axis.

 

Abstract

1. Intact absorption of the bioactive dipeptide Val-Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10-fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 +/- 145 vs 159 +/- 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t1/2) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 +/- 688 fmol small middle doth/mL plasma.

PMID:

11906484

DOI:

10.1046/j.1440-1681.2002.03628.x

[Indexed for MEDLINE]

https://www.ncbi.nlm.nih.gov/pubmed/11906484

Renin-angiotensin system , many faces

https://benthamopen.com/FULLTEXT/TOOPHTJ-11-122

 

Youll find here a very good map of RAS and  KKK system! https://openophthalmologyjournal.com/VOLUME/11/PAGE/122/