Cardasil on focus_A controversial vaccin, made up of proteins = a unique vaccination.

November 7, 2015

Group No.: 2
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Author: Associated Press
News Paper: N/A
Area Key Word: HPV, amino acids, zwitter ion, immunochemistry, catalytic antibodies
Chemistry Key Word: sterile preparation, aluminium hydrophosphate sulfate, L-histidine, polysorbate 80
Editorial Comment: Gardasil (quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine) is a controversial vaccine that has been on the market a little over a year now. The vaccine is given to adolescent girls to prevent certain strains of cervical cancer and genital warts. The disease can be prevented through a simple vaccination; however the vaccination has become quite controversial. Does the vaccine prevent all forms of cervical cancer? The idea of a “cancer vaccine” is quite new, and Gardasil is currently the most expensive vaccine on the market. Texas is one of the first states to make it mandatory for women to recieve the vaccination. Is Colorado next? HPV Vaccine Bill approved by Colorado Senate

The Gardasil vaccination is a unique vaccination because it is composed of proteins and does not have a chemical structure. The vaccination is composed of virus like particles or VLP’s. The proteins are synthesized by the bacteria Saccharomyces cerevisiae.
Gardasil remains a hotly debated topic in government and in school systems across the United States. The vaccine is attributed to preventing cancer, but is also known for leading to the deaths of some young women. As research continues, society will be presented with the challenge of accepting this controversial vaccine.
This project highlights the chemical ingredients in Gardasil and addresses important, yet different aspects of the vaccine. The chemical focus lies within the proteins of the vaccine. The reaction diagram represented here explains the zwitterion which is explained in detail in question #2.
The zwitterion is essential in understanding amino acids, proteins and the way these correspond to organic chemistry.
The diagram shows an unionized amino acid (left) converting to a zwitterion (right).Note: Not all proteins have “S” stereochemistry. Although the zwitterion exists as “S”, some proteins exist as “L”.

Gardasil information in Spanish

Question 1: The Gardasil vaccine is made up of proteins, but how are these proteins made?
Answer 1: All papillomaviruses have a capsid, or shell that is made up of proteins.
The Gardasil vaccine contains purified L1 proteins for the 4 types of human papillomaviruses: 6,11,16,18.
Further, proteins are made up of amino acids:
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