The Nobel Assembly about avermectin and artemisin, anti-parasite drugs. Scientific background

October 6, 2015

http://www.nobelprize.org/nobel_prizes/medicine/laureates/2015/advanced-medicineprize2015.pdf

http://www.nature.com/news/anti-parasite-drugs-sweep-nobel-prize-in-medicine-2015-1.18507

Three scientists who developed therapies against parasitic infections have won this year’s Nobel Prize in Physiology or Medicine.

The winners are: William C. Campbell, a microbiologist at Drew University in Madison, New Jersey; Satoshi Ōmura, a microbiologist at Kitasato University in Japan; and Youyou Tu, a pharmacologist at the China Academy of Chinese Medical Sciences in Beijing.

In the 1970s, Campbell and Ōmura discovered a class of compounds, called avermectins, that kill parasitic roundworms that cause infections such as river blindness and lymphatic filariasis. The most potent of these was released onto the market in 1981 as the drug ivermectin.

Tu, who won a Lasker prize in 2011, developed the antimalarial drug artemisinin in the late 1960s and 1970s. She is the first China-based scientist to win a science Nobel. “This certainly is fantastic news for China. We expect more to come in the future,” says Wei Yang, president of the nation’s main research-funding agency, the National Natural Science Foundation of China.

 

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