How bad is Cholera? Development of novel vaccine strains.

October 18, 2014

CHOLERA is the most severe of the bacterial diarrhoeal  diseases and has affected human populations for centuries; since the beginning of the 19th century it has spread throughout the world. Today there are an estimated 1.4- 4.3 million cases of cholera annually world-wide with more than 140 000 deaths with case-fatality rate (CFR) up to 5% during 2013. These numbers however are likely to be heavily under-estimated due to limitations of surveillance systems, lack of laboratory diagnostics or fear of a negative impact on travel and trade. It is estimated that 2.5 billion people are living with the risk of cholera and other diarrhoeal diseases. CHOLERA is caused by the bacterium Vibrio cholerae and it is an acute, often severe diarrhoeal disease which can be fatal It is particularly dangerous for young children. ( Citate from the introduction of the thesis of  Dr. Stephan Karlsson)

Thesis:

Stefan Karlsson. Development of novel  vaccin strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera.  Institute of Biomedicine at Sahlgrenska Academy, university of Gothenburg  ISBN 978-91-628-9122-0

Disputation  17th Oct 2014

http://hdl.handle.net/2077/35959

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